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By running [email protected] on your computer when you're not using it you will speed up and extend our efforts to design new proteins and to predict their 3-dimensional shapes. Proteins are the molecular machines and building blocks of life. You can read more about protein folding and design here .

Wiki info

The [email protected] application and the BOINC distributed computing platform are available for the operating systems Windows, Linux, and macOS; BOINC also runs on several others, e. g. , FreeBSD. Participation in [email protected] requires a central processing unit (CPU) with a clock speed of at least 500 MHz, 200 megabytes of free disk space, 512 megabytes of physical memory, and Internet connectivity. As of July 20, 2016, the current version of the Rosetta Mini application is 3. 73. The current recommended BOINC program version is 7. 6. 22. Standard Hypertext Transfer Protocol (HTTP) (port 80) is used for communication between the user's BOINC client and the [email protected] servers at the University of Washington; HTTPS (port 443) is used during password exchange. Remote and local control of the BOINC client use port 31416 and port 1043, which might need to be specifically unblocked if they are behind a firewall. Workunits containing data on individual proteins are distributed from servers located in the Baker lab at the University of Washington to volunteers' computers, which then calculate a structure prediction for the assigned protein. To avoid duplicate structure predictions on a given protein, each workunit is initialized with a random seed number. This gives each prediction a unique trajectory of descent along the protein's energy landscape. Protein structure predictions from [email protected] are approximations of a global minimum in a given protein's energy landscape. That global minimum represents the most energetically favorable conformation of the protein, i. e. , its native state.

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